A brace from Alex Curran condemned Droylsden to a 3-1 defeat to Colne at Holt House.
Curran fired past Richie Branagan to open the scoring inside 23 minutes, before he added a second from short range shortly after half-time.
Stephen Hall pulled one back for the Bloods, but any hopes of a draw were quashed by Connor Hughes as he guided Bradley Knox’s cross into the net.
10-man Mossley were thumped 5-1 by Goole AFC as Jordan Turner netted a hat-trick at the Victoria Pleasure Grounds.
The game’s turning-point came in the 16th minute as Mossley’s Logan Jeffs was sent off for blocking Danny South’s goal-bound header with his arm, with Turner netting the resulting penalty.
Sam Colbear rose highest to head home from a corner to make it 2-0, before Turner tucked in his second penalty of the afternoon.
The Lilywhites did get on the scoresheet in the 66th minute when Liam Ellis bundled the ball home after Goole goalkeeper Ben Saynor spilled Jack Tuohy’s corner.
However, Turner completed his hat-trick with 15 minutes remaining before Colbear’s second header rounded off a miserable afternoon for Mossley.
Trafford were thrashed 5-0 by Bamber Bridge at Irongate.
Kieran Charnock headed in and Lewis Nightingale curled home a superb strike as Brig went into the break two to the good.
Regan Linney netted a third as he slotted past Grant Shenton nine minutes into the second half.
Chris Marlow and James Boyd added late goals for the hosts.